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Lowered Cutaneous and Urinary Levels of Polyamines With Clinical Improvement in Treated Psoriasis
Michael S. Proctor, MD;
David I. Wilkinson, PhD;
Elaine K. Orenberg, PhD;
Eugene M. Farber, MD
Arch Dermatol. 1979;115(8):945-949.
Abstract
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Polyamine metabolism is important in cell proliferation and may play a role in the epidermal cell hyperproliferation of psoriasis. We have determined changes in polyamine levels in skin and urine accompanying clinical improvement in psoriasis following topical therapy. Nine hospitalized patients were examined at the beginning and end of their courses of treatment. Skin biopsy specimens and portions of 24-hour urine collections were analyzed for polyamines with a modified automatic amino acid analyzer. Treatment resulted in lower cutaneous levels of putrescine (by 50%, P <.05), spermidine (by 24%, P <.05), and spermine (by 35%, P <.005), and lower urinary levels of spermidine (by 20%, P <.025) and spermine (by 35%, P <.025). These results suggest that in psoriasis, the skin significantly contributes to the levels of spermidine and spermine in systemic fluids. Topical therapy may reduce epidermal cell proliferation in psoriasis by lowering polyamine levels.
(Arch Dermatol 115:945-949, 1979)
Author Affiliations
From the Department of Dermatology, Stanford (Calif) Medical Center (Drs Proctor, Wilkinson, Orenberg, and Farber).
Footnotes
Accepted for publication March 1, 1979.
Presented in part as the Nelson Paul Anderson Memorial Essay at the 30th Annual Meeting of the Pacific Dermatologic Association, San Diego, Sept 19, 1978, and in part at the 37th Annual Meeting of the American Academy of Dermatology, San Francisco, Dec 5, 1978.
Reprint requests to the Department of Surgery, Stanford University Medical Center, Stanford, CA 94305 (Dr Proctor).
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ABSTRACT
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