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Psoralens Plus Long-Wave Ultraviolet Radiation With Betamethasone Valerate

C. William Hanke, MD; Willard D. Steck, MD; Henry H. Roenigk, Jr, MD

Arch Dermatol. 1979;115(9):1074-1077.

Abstract
In the treatment of psoriatic patients with psoralens plus long-wave ultraviolet radiation (PUVA), clearing of psoriatic lesions was obtained more quickly and with smaller doses of ultraviolet light when topically applied corticosteroid therapy was added. Twelve patients with symmetrical plaque-type psoriasis were given PUVA on one side of the body and PUVA plus betamethasone valerate on the other side in a paired comparison study. Ten of the patients had faster clearing of lesions on the side that was treated with PUVA and betamethasone than on the side treated with PUVA alone. The other two patients had equal clearing on both sides. All patients remained clear of lesions during maintenance with PUVA alone for at least five months after steroid therapy was discontinued. Combination therapy may save the patient time, expense, and unnecessary exposure to radiant energy.

(Arch Dermatol 115:1074-1077, 1979)

Author Affiliations
From The Cleveland Clinic Foundation and The Cleveland Clinic Educational Foundation. Dr Roenigk is now with the Department of Dermatology, Northwestern University Medical School, Chicago.

Footnotes
Accepted for publication Feb 13, 1979.

Read before the 36th annual meeting of the American Academy of Dermatology, Dallas, Dec 6, 1977.

Reprint requests to Department of Dermatology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44106 (Dr Steck).

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