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Daniel N. Sauder, MD; Philip L. Bailin, MD; James Sundeen, MS; Randall S. Krakauer, MD

Arch Dermatol. 1980;116(1):51-55.

Abstract
• Recent studies suggest that autoimmunity may play a role in the pathogenesis of psoriasis. In view of these findings, it is postulated that the immunologic defect may be associated with regulation of the immune system. A study was undertaken to determine whether a suppressor cell defect was present. Two groups of patients with active psoriasis who were receiving no therapy were selected. Peripheral blood lymphocytes were pulsed with concanavalin A, 40 µg/cc, for 48 hours. Their ability to suppress a mixed lymphocyte reaction with both autologous and allogeneic responding cells was assessed. There was a significant decrease in suppressor activity in psoriasis patients compared with normal individuals. Although we have not demonstrated that this mechanism is implicated directly in a causal relationship to psoriasis, it nevertheless gives further support to the possible role of the immune system in the pathogenesis of psoriasis.

(Arch Dermatol 116:51-55, 1980)

Author Affiliations
From the Departments of Dermatology (Drs Sauder and Bailin) and Immunology (Mr Sundeen and Dr Krakauer), The Cleveland Clinic Foundation. Dr Krakauer is a fellow of the Arthritis Foundation. Dr Sauder is now with the Dermatology Branch, National Cancer Institute, Bethesda, Md.

Footnotes
Accepted for publication April 24, 1979.

Preliminary data presented at the Eighth International Congress of the Reticuloendothelial Society, Jerusalem, June 17, 1978.

Reprint requests to Dermatology Branch, National Cancer Institute, Bethesda, MD 20014 (Dr Sauder).

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