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Ronald A. Katz, MD; Hildegard Jorgensen, RN; Thomas P. Nigra, MD

Arch Dermatol. 1980;116(12):1369-1372.

Abstract
• Ten patients with disorders of keratinization were treated with oral isotretinoin (13-cis-retinoic acid) on an investigational protocol to test the efficacy, safety, and optimal dosage schedule for using the drug in these rare disorders. Elevations of serum triglyceride levels above the highest normal levels developed in seven of the ten patients, while they maintained normal levels of serum cholesterol. This effect was found to be dose and/or time related and reversible. Moderate elevations of serum triglyceride levels have not been clearly established as a risk factor for the development of coronary artery disease. High levels, however, may precipitate acute pancreatitis. For this reason, the conditions of patients receiving retinoids must be carefully monitored for triglyceride abnormalities throughout their courses of treatment.

(Arch Dermatol 116:1369-1372, 1980)

Author Affiliations
From the Department of Dermatology, The Washington Hospital Center, Washington, DC.

Footnotes
Accepted for publication March 13, 1980.

Reprint requests to the Department of Dermatology, The Washington Hospital Center, 110 Irving St NW, Washington, DC 20010 (Dr Katz).

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