This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (94)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Consideration of Liver Biopsies at Regular Intervals

June K. Robinson, MD; Richard D. Baughman, MD; Robert Auerbach, MD; Robert J. Cimis, MD

Arch Dermatol. 1980;116(4):413-415.

Abstract
Fibrosis of the liver developed to a degree that contraindicated further treatment with methotrexate in 11 of 43 patients who had been receiving maintenance therapy with methotrexate for psoriasis. Liver biopsy had been performed prior to initiation of methotrexate therapy and was repeated at 12- to 18-month intervals. In this retrospective study, age of the patient and duration of therapy have been found to be significant factors in those patients receiving only the weekly oral dosage schedule. Yearly biopsies of the liver are recommended for patients who receive methotrexate throughout their courses of therapy.

(Arch Dermatol 116:413-415, 1980)

Author Affiliations
From the Department of Medicine, Sections of Dermatology (Drs Robinson and Baughman) and Gastroenterology/Hepatology (Dr Cimis), Mary Hitchcock Memorial Hospital, Hanover, NH, and the Department of Dermatology, New York University School of Medicine (Dr Auerbach). Dr Robinson is now with the Department of Dermatology, Northwestern University School of Medicine, Chicago.

Footnotes
Accepted for publication Sept 21, 1979.

Reprint requests to Department of Dermatology, Northwestern University School of Medicine, 303 E Chicago Ave, Chicago, IL 60611 (Dr Robinson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Analysis of Risk Factors in Psoriatic Patients With Methotrexate-Induced Increases in Transaminase Levels
Heydendael et al.
Arch Dermatol 2004;140:1289-1290.
FULL TEXT  

Detection of Hepatotoxicity Associated With Methotrexate Therapy for Psoriasis
O'Connor et al.
Arch Dermatol 1989;125:1209-1217.
ABSTRACT  

The Role of Liver Biopsies in Psoriatic Patients Receiving Long-term Methotrexate Treatment: Improvement in Liver Abnormalities After Cessation of Treatment
Newman et al.
Arch Dermatol 1989;125:1218-1224.
ABSTRACT  

Dose-dependent Acute Hepatitis Associated with Administration of High Dose Methotrexate
Banerjee et al.
Hum Exp Toxicol 1988;7:561-562.
 

Primary Sclerosing Cholangitis and Low-Dose Oral Pulse Methotrexate Therapy: Clinical and Histologic Response
KAPLAN et al.
ANN INTERN MED 1987;106:231-235.
ABSTRACT  

Methotrexate Pharmacokinetics in Psoriatic Patients Developing Hepatic Fibrosis
Jones et al.
Arch Dermatol 1986;122:666-669.
ABSTRACT  

Methotrexate Treatment of Rheumatoid Arthritis
WILLKENS
ANN INTERN MED 1985;103:612-613.
ABSTRACT  

Liver Biopsies v Liver Scans in Methotrexate-Treated Patients With Psoriasis
Geronemus et al.
Arch Dermatol 1982;118:649-651.
ABSTRACT  

Methotrexate and Ultraviolet Radiation
Armstrong and Poh-Fitzpatrick
Arch Dermatol 1982;118:177-178.
ABSTRACT