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A Newly Recognized Disease

Kirsti-Maria Niemi, MD; Svante Stenman, MD; Georg H. Borgström, MD; Timo Vihersaari, MD; Jorma Viikari, MD; Urpo Kiistala, MD

Arch Dermatol. 1980;116(5):580-583.

Abstract
• A disease characterized by massive tumorous cutaneous hyalinosis has been studied histologically, immunologically, and biochemically. The precipitated hyalin material differed from amyloid in being Congo-red-negative and ultrastructurally nonfibrillary. In lipoid proteinosis, massive hyalin deposits have not been encountered and the clinical course is distinct from the course of massive cutaneous hyalinosis. The clinical and histologic pictures of both adult and juvenile forms of colloid milium differed from that found in our patient, although the colloid milium in adult form is ultrastructurally also nonfibrillary like the hyalin from our patient. A strong humoral immune response to components of the cytoskeleton of fibroblasts and especially to keratin was found in our patient.

(Arch Dermatol 116:580-583, 1980)

Author Affiliations
From the Department of Dermatology and the Fourth Department of Medicine, Helsinki University Central Hospital, Helsinki.

Footnotes
Accepted for publication Dec 18, 1979.

Reprint requests to the Department of Dermatology, Helsinki University Central Hospital, Snellmaninkatu 14, 00170 Helsinki 17, Finland (Dr Niemi).

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