This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (15)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical and Histopathologic Study of Nine Cases

Eric W. Herman; Jeffrey S. Kezis, MD; David N. Silvers, MD

Arch Dermatol. 1981;117(1):26-28.

Abstract
• We describe here nine women who had similar distinctive clinical features that consisted of painful red-to-purple macules, papules, and plaques on the digits, predominantly on the toes. All patients reported that exposure to cold had preceded their symptoms. Histologic study demonstrated a lymphocytic vasculitis, characterized by lymphocytes infiltrating the walls of blood vessels in eight (88%) of nine lesions. This pattern of inflammation is different from the perivascular lymphocytic infiltrate that is common to lupus erythematosus, erythema multiforme, lymphocytic infiltration of the skin (Jessner), and drug eruptions. It also serves to distinguish the disorder from other clinical conditions resembling it, such as cellulitis, herpes simplex infection, and disseminated gonococcemia. To the best of our knowledge, this lymphocytic vasculitis has not been previously described as occurring in pernio. We believe the unique disorder that we are reporting is a common, but infrequently recognized, variant of pernio.

(Arch Dermatol 117:26-28, 1981)

Author Affiliations
From the Dermatology Service, US Public Health Service Hospital, Staten Island, NY (Dr Herman), and the Departments of Dermatology (Drs Silvers and Kezis) and Pathology (Dr Silvers), College of Physicians and Surgeons of Columbia University, New York.

Footnotes
Accepted for publication March 31, 1980.

Reprint requests to Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168th St, New York, NY 10032 (Dr Silvers).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Chronic Pernio: A Historical Perspective of Cold-Induced Vascular Disease
Jacob et al.
Arch Intern Med 1986;146:1589-1592.
ABSTRACT  

Pernio: A Possible Association With Chronic Myelomonocytic Leukemia
Kelly and Dowling
Arch Dermatol 1985;121:1048-1052.
ABSTRACT