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Dapsone HypersensitivityThe Sulfone Syndrome Revisited
Kenneth J. Tomecki, MD;
Charles J. Catalano, MD
Arch Dermatol. 1981;117(1):38-39.
Abstract
• A hypersensitivity reaction to low-dose (50-mg), short-term daspone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this "sulfone syndrome," an uncommon, potentially serious, side effect of dapsone therapy.
(Arch Dermatol 117:38-39, 1981)
Author Affiliations
From the Division of Dermatology, Department of Medicine, University of Florida College of Medicine, Gainesville. Dr Tomecki is now with the Department of Dermatology, Cleveland Clinic Foundation.
Footnotes
Accepted for publication July 25, 1980.
Reprint requests to the Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44106 (Dr Tomecki).
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