 |
|
Antibodies to MelanocytesOccurrence in Patients With Vitiligo and Chronic Mucocutaneous Candidiasis
Nancy Howanitz, MD;
James L. Nordlund, MD;
Aaron B. Lerner, MD;
Jean-Claude Bystryn, MD
Arch Dermatol. 1981;117(11):705-708.
Abstract
• The prevalence of antibodies to melanocytes was determined by an immunofluorescence complement fixation technique in 294 patients with vitiligo, other pigmentary disorders, and unrelated dermatoses. Antimelanocyte antibodies were present in the sera of five (29%) of 17 patients with chronic mucocutaneous candidiasis. Only two of the five patients with antibodies had vitiligo. No antibodies to melanocytes were found in the sera of 31 patients with common vitiligo or of 38 patients with vitiligo associated with autoimmune diseases or melanoma. Nor were antibodies to melanocytes found in 129 patients with other diseases of pigment-producing cells or in a control group of 79 patients with nonpigmentary dermatoses. These results suggest that complement fixing antibodies to melanocytes are associated with chronic mucocutaneous candidiasis but are not involved in the pathogenesis of common vitiligo.
(Arch Dermatol 1981;117:705-708)
Author Affiliations
From the Immunofluorescence Laboratory, Department of Dermatology (Drs Howanitz and Bystryn), New York University School of Medicine, New York; and the Departments of Dermatology, Yale University School of Medicine (Dr Lerner) and the West Haven Veterans Administration Medical Center (Dr Nordlund), New Haven, Conn.
Footnotes
Accepted for publication Jan 9, 1981.
Reprint requests to Department of Dermatology, New York University School of Medicine, 560 First Ave, New York, NY 10016 (Dr Bystryn).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Vitiligo Antibodies Are Not Directed to Tyrosinase
Xie et al.
Arch Dermatol 1999;135:417-422.
ABSTRACT
| FULL TEXT
Nutrition and Its Relationship to Autism
Adams and Conn
Focus Autism Other Dev Disabl 1997;12:53-58.
ABSTRACT
Complement-Fixing Activity to Melanin-Producing Cells Preceding the Onset of Vitiligo in a Patient With Type 1 Polyglandular Failure
Betterle et al.
Arch Dermatol 1992;128:123-124.
ABSTRACT
Autoantibodies and Their Clinical Significance in a Black Vitiligo Population
Grimes et al.
Arch Dermatol 1983;119:300-303.
ABSTRACT
Chronic Mucocutaneous Candidosis: An Update
Jorizzo
Arch Dermatol 1982;118:963-965.
ABSTRACT
Vitiligo: It Is Important
Nordlund and Lerner
Arch Dermatol 1982;118:5-8.
ABSTRACT
|
