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Suppressor Cell Dysfunction and Necrotizing Lesions in a Child
Stephen J. McGeady, MD;
Ofelia Buella;
Ralph Heimer, PhD;
Herbert C. Mansmann, Jr, MD
Arch Dermatol. 1981;117(2):93-98.
Abstract
• A girl had opportunistic infections and was found to have T-cell dysfunction. During a period of months, recurrent staphylococcal infections, polyclonal hyperglobulinemia, eosinophilia, and peripheral, necrotizing, cutaneous lesions developed. Circulating immune complexes were demonstrated, and abnormal suppressor-cell function was found. At age 36 months, the child died of a staphylococcal pneumonia. At postmortem examination, the thymus gland was found to be histologically abnormal, lacking corticomedullary differentiation. We propose that this patient had a syndrome in which lymphocyte abnormalities and dysfunction of suppressor T cells permitted hyperresponsiveness of antibody-forming cells. Large amounts of circulating antibody and immune complexes were formed, and their deposition led to peripheral tissue injury.
(Arch Dermatol 117:93-98, 1981)
Author Affiliations
From the Departments of Pediatrics and Biochemistry, Thomas Jefferson University, Jefferson Medical College, Philadelphia.
Footnotes
Accepted for publication April 18, 1980.
Reprint requests to 1025 Walnut St, Philadelphia, PA 19107 (Dr McGeady).
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