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Anti-Pigment-Cell Factors and Mucocutaneous Candidiasis
James J. Nordlund, MD;
Nancy Howanitz, MD;
Jean Claude Bystryn, MD;
Bernadette M. Forget, RN, MSN;
Aaron B. Lerner, MD
Arch Dermatol. 1981;117(4):210-212.
Abstract
• Previous reports document the fact that some patients with mucocutaneous candidiasis and vitiligo have a complementfixing anti-pigment-cell factor in their serum. We examined sera from seven patients with mucocutaneous candidiasis without vitiligo. Three of the seven sera contained the anti-pigment-cell factor. We suggest that these anti-pigment-cell factors, which are most probably antibodies, are not cytotoxic for pigment cells and, thus, not the cause of vitiligo. The association of vitiligo and anti-pigment-cell factors with the syndrome of mucocutaneous candidiasis implicates the immune system as a causal factor of vitiligo.
(Arch Dermatol 1981;117:210-212)
Author Affiliations
From the Department of Dermatology, West Haven (Conn) Veterans Administration Medical Center (Dr Nordlund); the Department of Dermatology, Yale University School of Medicine, New Haven, Conn (Ms Forget and Dr Lerner); and the New York University Medical Center (Drs Howanitz and Bystryn).
Footnotes
Accepted for publication July 28, 1980.
Reprint requests to West Haven Veterans Administration Medical Center, West Haven, CT 06516 (Dr Nordlund).
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