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Chronic Bullous Disease With Coexistent Circulating IgG and IgA Anti-Basement Membrane Zone Antibodies
Sachiko Miyagawa, MD;
Yasuo Kiriyama, MD;
Toshihiko Shirai, MD;
Hideo Ohi, MD;
Kuniki Sakamoto, MD
Arch Dermatol. 1981;117(6):349-353.
Abstract
Coexistent circulating IgG and IgA anti-basement membrane zone (BMZ) antibodies were demonstrated in a patient with chronic bullous disease. Direct immunofluorescence microscopy showed IgG, IgA, and C3 deposits in a linear pattern at the BMZ in the patient's uninvolved skin. Ultrastructurally, the bulla was formed beneath the basal lamina as in dermatitis herpetiformis. This investigation might provide evidence for the immunologic overlap of bullous pemphigoid and dermatitis herpetiformis.
(Arch Dermatol 1981;117:349-353)
Author Affiliations
From the Department of Dermatology, Nara Medical University, Nara, Japan.
Footnotes
Accepted for publication Aug 22, 1980.
Reprint requests to Department of Dermatology, Nara Medical University, Nara 634, Japan (Dr Miyagawa).
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