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Eugene W. Monroe, MD; Steven H. Cohen, MD; John Kalbfleisch, PhD; Caryn I. Schulz, MD

Arch Dermatol. 1981;117(7):404-407.

Abstract
• Chronic urticaria is a frustrating problem for the patient and the physician. The cause is usually undetermined, and the therapy is directed toward controlling symptoms. Recent evidence that human skin blood vessels possess H₂ receptors, as well as the commonly recognized H₁ receptors, suggests a possible reason for the frequent failure of H₁ antihistamines in controlling this disorder. Eighteen patients with refractory chronic idiopathic urticaria participated in a double-blind, cross-over study to evaluate the efficacy of combined H (hydroxyzine hydrochloride) and H₂ (cimetidine) antihistamines vs H₁ antihistamines alone. This study indicates that combined H₁ and H₂ antihistamine therapy is statistically more effective than H¹ antihistamines alone in controlling the symptoms of chronic urticaria.

(Arch Dermatol 1981;117:404-407)

Author Affiliations
From the Sections of Dermatology (Drs Monroe and Schulz) and Allergy (Dr Cohen), Department of Medicine, Medical College of Wisconsin; the Research Service, Wood Veterans Administration Medical Center (Dr Kalbfleisch); and Milwaukee Medical Clinic SC (Dr Monroe), Milwaukee.

Footnotes
Accepted for publication Sept 23, 1980.

Read in part before the 38th annual meeting of the American Academy of Dermatology, Chicago, Dec 4, 1979.

Reprint requests to Milwaukee Medical Clinic SC, 3003 W Good Hope Rd, Milwaukee, WI 53209 (Dr Monroe).

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