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Immunopathologic Studies

Janet G. Tindall, MD; Thomas H. Rea, MD; Ira Shulman, MD; Francisco P. Quismorio, Jr, MD

Arch Dermatol. 1981;117(8):510-512.

Abstract
• A 28-year-old woman had an intensely pruritic eruption, consisting of plaques and vesicobullous lesions, three days after removal of a hydatidiform mole. Direct immunofluorescence (IF) microscopy of involved skin showed the linear deposition of C3 but no immunoglobulin along the basement membrane zone. Indirect IF microscopy disclosed a serum complement-fixing IgG antibody that reacted with the basement membrane of human adult and fetal skin. Thus, herpes gestationis can occur in association with a hydatidiform mole.

(Arch Dermatol 1981;117:510-512)

Author Affiliations
From the Sections of Dermatology (Drs Tindall and Rea) and Clinical Immunology and Rheumatic Diseases (Dr Quismorio), and the Departments of Medicine and Pathology (Dr Shulman), University of Southern California School of Medicine, Los Angeles.

Footnotes
Accepted for publication Jan 7, 1981.

Reprint requests to Section of Clinical Immunology and Rheumatic Diseases, University of Southern California School of Medicine, 2025 Zonal Ave, Los Angeles, CA 90033 (Dr Quismorio).

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