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Sanford I. Roth, MD; Heinrich K. Schedewie, MD; Victoria K. Herzberg, PhD; Jerrald Olefsky, MD; M. Joycelyn Elders, MD; Arthur Rubenstein, MD

Arch Dermatol. 1981;117(9):531-535.

Abstract
• Three patients who had leprechaunism were noted to have cutaneous alterations consistent with acanthosis nigricans. In addition, these patients had hypertrichosis and dysplastic nails. The biochemical hallmarks of this disease are hyperinsulinemia and fasting hypoglycemia. The biochemical findings and an abnormality of insulin binding may be the basis for the development of these characteristic cutaneous lesions.

(Arch Dermatol 1981;117:531-535)

Author Affiliations
From the Departments of Pathology (Dr Roth) and Pediatrics (Drs Schedewie, Herzberg, and Elders), University of Arkansas College of Medicine, Little Rock; the Department of Medicine, University of Colorado School of Medicine, Denver (Dr Olefsky); and the Department of Medicine, University of Chicago School of Medicine (Dr Rubenstein).

Footnotes
Accepted for publication Feb 18, 1981.

Reprint requests to Department of Pathology, University of Arkansas College of Medicine, 4301 W Markham, Little Rock, AR 72205 (Dr Roth).

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