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Paul J. Ruschak, MD; Young C. Kauh, MD; Herbert A. Luscombe, MD

Arch Dermatol. 1981;117(9):573-575.

Abstract
• Cowden's disease is an autosomal dominant disease characterized by verrucous lesions, mucosal papules, and trichilemmomas associated with gastrointestinal tract, thyroid, CNS, and musculoskeletal abnormalities. In addition, our patient exhibited a deficiency of T-lymphocyte function, with recurrent cellulitis and abscess formation, and the eventual development of acute myelogenous leukemia. The defect in T-lymphocyte function may help to explain the higher incidence of malignant neoplasms in patients with Cowden's disease. We recommend complete immunologic examination of patients with this disorder.

(Arch Dermatol 1981;117:573-575)

Author Affiliations
From the Department of Dermatology, Thomas Jefferson University, Jefferson Medical College, Philadelphia.

Footnotes
Accepted for publication Feb 18, 1981.

Reprints not available.

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ABSTRACT