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Tetracycline and Minocycline TreatmentEffects on Skin-Surface Lipid Levels and Propionibacterium acnes
James J. Leyden, MD;
Kenneth J. McGinley;
Albert M. Kligman, MD, PhD
Arch Dermatol. 1982;118(1):19-22.
Abstract
• The effect of 1,000 mg of tetracycline hydrochloride and 200 mg of minocycline hydrochloride on Propionibacterium acnes levels and skin-surface lipid levels was measured in 15 patients with acne. Minocycline produced a significantly greater reduction in the P acnes counts that persisted even up to three weeks after discontinuation of the minocycline therapy, in contrast to the return of P acnes to baseline counts within three weeks after discontinuation of the tetracycline therapy. A similar persistence of effect for reduction of skin-surface free fatty acid levels and clinical lesions was also seen with minocycline therapy.
(Arch Dermatol 1982;118:19-22)
Author Affiliations
From the Department of Dermatology, Duhring Laboratories, University of Pennsylvania, Philadelphia.
Footnotes
Accepted for publication April 9, 1981.
Reprint requests to Department of Dermatology, Duhring Laboratories, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104 (Dr Leyden).
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