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D. Geoffrey Shulman, MD; Ralph D. Wilkinson, MD, FRCP(C); Nhiem Nguyen, MD, FRCP(C)

Arch Dermatol. 1982;118(11):909-912.

Abstract
A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.

(Arch Dermatol 1982;118:909-912)

Author Affiliations
From the Division of Dermatology, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal.

Footnotes
Accepted for publication Dec 16, 1981.

Reprints not available.

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