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Dominick J. Ligresti, MD; John C. Neff, MD; Edmund D. Lowney, MD

Arch Dermatol. 1982;118(12):966-970.

Abstract
• Numerous investigations have suggested an immunologic pathogenesis of psoriasis and diminished suppressor T-cell activity of psoriatic blood. Consequently, a study was undertaken to explain whether diminished suppressor cell activity was a result of quantitative alterations of the T-lymphocyte subpopulation. Twenty patients with psoriasis and 20 normal control subjects were randomly selected. Our findings demonstrated a significant decrease in the percentage of suppressor cells (T), a significant elevation of helper cells (T_µ), and a highly significant increase in the helper-suppressor T-cell ratio (T_µ/T) of psoriatic blood compared with that of normal control subjects. Our study gives further support to the possible role of immunologic factors in the pathogenesis of psoriasis.

(Arch Dermatol 1982;118:966-970)

Author Affiliations
From the Departments of Dermatology (Drs Ligresti and Lowney) and Pathology (Dr Neff), Ohio State University Hospitals, Columbus.

Footnotes
Accepted for publication Jan 27, 1982.

Reprints not available.

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