 |
|
Immunofluorescent Staining With Antibodies to Factor VIII, Fibronectin, and Collagenous Basement Membrane Protein in Normal Human Skin and Port Wine Stains
James L. Finley, MD;
Robert A. F. Clark, MD;
Robert B. Colvin, MD;
Robert Blackman;
Joel Noe, MD;
Seymour Rosen, MD
Arch Dermatol. 1982;118(12):971-975.
Abstract
• Specific antibodies directed against three important components of the vessel wall (collagenous basement membrane protein-type IV collagen, fibronectin, and factor VIII) were used to study and compare the distribution of these proteins in normal skin and port wine stains. Collagenous basement membrane protein was localized to the basement membrane and basal lamina zones of blood vessels, appendages, arrector pili muscles, endoneurium and perineurium, and the dermoepidermal junction of both port wine stains and normal skin. Vessels of the port wine stain as well as those of normal skin showed a similar narrow uniform homogeneous line of fluorescence. Granular endothelial staining was seen in the blood vessels of both normal skin and port wine stains. The distribution of fibronectin was that of a low-intensity punctate pattern situated in the subendothelial region of both port wine stain and normal vessels and in the basement membrane zones of hair follicles, endoneurium and perineurium, and the dermoepidermal junction.
(Arch Dermatol 1982;118:971-975)
Author Affiliations
From the Departments of Pathology, Beth Israel Hospital (Drs Finley, Clark, Noe, and Rosen), Massachusetts General Hospital (Dr Colvin), and Harvard Medical School (Drs Finley, Clark, Colvin, Noe, and Rosen), Boston; and Brandeis University, Waltham, Mass (Mr Blackman). Dr Clark was a Fellow of the Society for Investigative Dermatology and the Boston Medical Foundation during these studies.
Footnotes
Accepted for publication Feb 17, 1982.
Read in part at the International Association of Pathology Meetings, Chicago, Feb 25, 1981.
Reprint requests to Beth Israel Hospital, 330 Brookline Ave, Boston, MA 00215 (Dr Finley).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Acquired Port-wine Stains and Antecedent Trauma: Case Report and Review of the Literature
Adams and Lucky
Arch Dermatol 2000;136:897-899.
ABSTRACT
| FULL TEXT
Pulsed Dye Laser-Resistant Port-wine Stains
Kane et al.
Arch Dermatol 1996;132:839-841.
ABSTRACT
Immunohistochemistry of Port-wine Stains and Normal Skin With Endothelium-Specific Antibodies PAL-E, Anti--ICAM-1, Anti--ELAM-1, and Anti--Factor VIIIrAg
Neumann et al.
Arch Dermatol 1994;130:879-883.
ABSTRACT
Acquired Persistent Erythematous Patch on the Neck
Flint and Wilkin
Arch Dermatol 1994;130:512-512.
ABSTRACT
Port-wine Stains: A Disease of Altered Neural Modulation of Blood Vessels?
Smoller and Rosen
Arch Dermatol 1986;122:177-179.
ABSTRACT
Port-wine Stains: Morphologic Variations and Developmental Lesions
Finley et al.
Arch Dermatol 1984;120:1453-1455.
ABSTRACT
Argon Laser-Port-Wine Stain Interaction: Immediate Effects
Finley et al.
Arch Dermatol 1984;120:613-619.
ABSTRACT
|
