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Epidermal Labeling Indexes, Polyamines, and Histopathologic Findings

Nicholas J. Lowe, MD, MRCP; Marc Chalet, MD; James Breeding; Charles Kean, DVM, PhD; Diane H. Russell, PhD

Arch Dermatol. 1982;118(12):993-996.

Abstract
• We have previously described the clinical and dermatopathologic features of a psoriasiform dermatosis in a rhesus monkey (Macaca mulatta). This animal has been studied further in attempts to characterize its skin disease. Epidermal cell DNA synthesis was measured following the intradermal injection of tritiated thymidine. Epidermal cell labeling indexes in the involved and uninvolved skin of the affected monkey and in the skin of a normal monkey were compared. The labeling indexes in the involved skin were significantly increased as compared with uninvolved skin; they were also significantly higher than in normal skin. Epidermal polyamine assays showed increased epidermal putrescine in involved skin together with increased spermidine and an increased spermidine-spermine ratio compared with uninvolved and normal skin sites.

(Arch Dermatol 1982; 118:993-996)

Author Affiliations
From the University of California, Los Angeles-Veterans Administration Wadsworth Dermatology Program (Drs Lowe and Chalet and Mr Breeding), and the Department of Animal Medicine, UCLA (Dr Kean); and the Department of Pharmacology, University of Arizona, Tucson (Dr Russell).

Footnotes
Accepted for publication Jan 6, 1982.

Reprint requests to Division of Dermatology, UCLA School of Medicine, Los Angeles, CA 90024 (Dr Lowe).

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