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Therapeutic Efficacy in the Treatment of Pyoderma Gangrenosum

Robert B. Johnson, MD; Gerald S. Lazarus, MD

Arch Dermatol. 1982;118(2):76-84.

Abstract
• Three patients with pyoderma gangrenosum were treated with suprapharmacologic doses of methylprednisolone sodium succinate using a five-day pulse therapy regimen. This therapy produced a dramatic remission with minimal side effects. The effects of pulse therapy are reviewed, and its role in severe steroid-responsive dermatoses is discussed.

(Arch Dermatol 1982;118:76-84)

Author Affiliations
From the Department of Medicine, Division of Dermatology, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication July 31, 1981.

Reprint requests to PO Box 2987, Duke University Medical Center, Durham, NC 27710 (Dr Lazarus).

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