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  Vol. 118 No. 4, April 1982 TABLE OF CONTENTS
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Fanconi's Anemia

Tumor-like Warts, Hyperpigmentation Associated With Deranged Keratinocytes, and Depressed Cell-Mediated Immunity

Eija Johansson, MD; Kirsti-Maria Niemi, MD; Martti Siimes, MD; Seppo Pyrhönen, MD

Arch Dermatol. 1982;118(4):249-252.


Abstract



• A 27-year-old man had had Fanconi's anemia (FA) for 20 years. The patient had pancytopenia, retarded growth, hypogonadism, and chromosomal aberrations. He had freckle-like and darker pigmented macules scattered on his chest, shoulders, upper part of the back, and hips, with interspersed, hypopigmented areas. Biopsy specimens taken from both the hyperpigmented and hypopigmented spots showed a derangement of keratinocytes and nuclear abnormalities, more notable on sunexposed skin sites. The patient also had numerous tumor-like, recalcitrant, viral warts. Immunologic studies showed normal humoral immunity, but there was evidence of depressed cell-mediated immunity. We speculate that the chromosomal aberrations, the depressed cell-mediated immunity, and the increased frequency of malignant neoplasms known to occur in patients with FA also reflect changes related to an increased susceptibility to viral infections.

(Arch Dermatol 1982;118:249-252)



Author Affiliations



From the Departments of Dermatology (Drs Johansson and Niemi) and Pediatrics (Dr Siimes), Helsinki University Central Hospital; and the Department of Virology, University of Helsinki (Dr Pyrhönen).


Footnotes



Accepted for publication Aug 6, 1981.

Reprints not available.



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Impaired Type I IFN-Induced Jak/STAT Signaling in FA-C Cells and Abnormal CD4+ Th Cell Subsets in Fancc-/- Mice
Fagerlie et al.
J. Immunol. 2004;173:3863-3870.
ABSTRACT | FULL TEXT  





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