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Mary C. Greist, MD; Warren W. Epinette, MD

Arch Dermatol. 1982;118(4):253-254.

Abstract
• Cimetidine, a histamine H₂-receptor antagonist, has previously been shown to have antiandrogenic activity in animals and to decrease the sebum excretion rate in humans. Two patients had generalized xerosis and asteatotic dermatitis that developed while they were receiving cimetidine therapy and resolved when cimetidine therapy was discontinued. We postulate that this skin change is related to the antiandrogenic properties of the drug and its effect on the sebum secretion rate.

(Arch Dermatol 1982;118:253-254)

Author Affiliations
From the Department of Dermatology, Indiana University School of Medicine, Indianapolis.

Footnotes
Accepted for publication Aug 18, 1981.

Reprint requests to Department of Dermatology, Indiana University School of Medicine, 1100 W Michigan St, Indianapolis, IN 46223 (Dr Greist).

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