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Clinical, Histologic, and Ultrastructural Study

Ernesto Bonifazi, MD; Ruggero Caputo, MD; Adriana Ceci, MD; Carlo Meneghini, MD

Arch Dermatol. 1982;118(4):267-272.

Abstract
• In a typical case of congenital self-healing histiocytosis of the Hashimoto-Pritzker type, the results of an ultrastructural examination of a nodule of a 30-day-old patient showed that about 25% of the cells contained Langerhans' granules and that approximately 40% of the cells contained unique phagosomes but no regularly laminated bodies. This case of congenital self-healing histiocytosis is an example of concurrent proliferation of two types of histiocytes (one with and one without Langerhans' granules). Since transitional forms were not observed, this finding might indicate the existence of congenital, self-healing forms of histiocytosis X.

(Arch Dermatol 1982;118:267-272)

Author Affiliations
From the Clinics of Dermatology (Drs Bonifazi and Meneghini) and Pediatrics (Dr Ceci), University of Bari, Italy; and the Clinic of Dermatology, Institute of Pharmacology, University of Milan, Italy (Dr Caputo).

Footnotes
Accepted for publication Sept 30, 1980.

Reprint requests to Clinica Dermatologica, Università di Milano, Via Pace 9, 20122 Milan, Italy (Dr Caputo).

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