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Treatment of Pustulosis Palmaris et Plantaris With Oral Doses of Colchicine
Masahiro Takigawa, MD;
Yoshiki Miyachi, MD;
Masami Uehara, MD;
Hachiro Tagami, MD
Arch Dermatol. 1982;118(7):458-460.
Abstract
• The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to 0.5 to 1 mg daily in responsive patients. Thirteen patients showed complete clearing of pustulation, and 14 patients showed a remarkable reduction in pustule formation after two to eight weeks of treatment. One patient did not respond and four discontinued treatment because of nausea or diarrhea. During a three-month follow-up evaluation after treatment was stopped, relapse occurred in eight cases. Colchicine appears to be effective in the suppression of acute exacerbations of pustulosis palmaris et plantaris.
(Arch Dermatol 1982;118:458-460)
Author Affiliations
From the Departments of Dermatology, Faculty of Medicine, Kyoto (Japan) University (Drs Takigawa and Miyachi); Shiga Medical School, Otsu, Japan (Dr Uehara); and Hamamatsu (Japan) Medical School (Dr Tagami).
Footnotes
Accepted for publication July 10, 1981.
Reprint requests to the Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan (Dr Takigawa).
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