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Its Association With Anti-Ro (SSA) Antibodies

Paul R. Vandersteen, MD; Thomas T. Provost, MD; Robert E. Jordon, MD; Frederic C. McDuffie, MD

Arch Dermatol. 1982;118(8):584-587.

Abstract
• C2 deficiency is the most common complement component deficiency. While individuals with C2 deficiency may be completely normal, a lupus erythematosus—like disease process has developed in some. A 28-year-old woman had a chronic photodermatitis, arthralgias, and mesangial lupus nephritis. She has C2 deficiency associated with an HLA-Dw2 transplantation antigen. Her serum has shown antibodies to the macromolecule Ro (the A antigen in Sjögren's syndrome), while failing to demonstrate antinuclear antibodies in routine laboratory determinations.

(Arch Dermatol 1982;118:584-587)

Author Affiliations
From the Department of Dermatology, the Fargo Clinic and the Division of Dermatology, University of North Dakota (Fargo) Medical School (Dr Vandersteen); the Department of Dermatology, The Johns Hopkins School of Medicine, Baltimore (Dr Provost); the Division of Dermatology, Department of Medicine, The Medical College of Wisconsin (Milwaukee) (Dr Jordon); and the Rheumatology Research Laboratory, the Mayo Clinic, Rochester, Minn (Dr McDuffie). Dr McDuffie is currently at the National Office of the Arithritis Foundation, Atlanta.

Footnotes
Accepted for publication March 28, 1982.

Read in part before the meeting of the Noah Worcester Dermatological Society, Newport Beach, Calif, March 22-28, 1981.

Reprint requests to Fargo Clinic, Fargo, ND 58123 (Dr Vandersteen).

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