This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Katsuro Ohyama, MD; Masato Kitoh, MD; Tatsuyoshi Arao, MD

Arch Dermatol. 1982;118(9):679-682.

Abstract
• Necrolytic migratory erythema is a disorder highly suggestive of glucagonoma syndrome. We carried out histologic and electron microscopic studies of the skin lesions in a 57-year-old woman with the glucagonoma syndrome. Light microscopic studies revealed hyperkeratosis, parakeratosis, formation of clefts in the upper epidermis, and scattered dyskeratotic cells. Ultrastructurally, the intercellular spaces were widened in the upper epidermis and desmosomes were reduced in number. The cytoplasm of affected cells showed vacuolar degeneration; the organelles were lysed or absent. There were scattered dark cells and dyskeratotic cells. These changes appear to represent a degenerative process of the keratinocytes.

(Arch Dermatol 1982;118:679-682)

Author Affiliations
From the Department of Dermatology, Kumamoto University Medical School, Kumamoto, Japan.

Footnotes
Accepted for publication Dec 12, 1981.

Reprint requests to Department of Dermatology, Kumamoto University Medical School, Honjo, Kumamoto, 860, Japan (Dr Ohyama).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Case Report of Superficial Necrolytic Dermatitis in a Beagle Dog with Diabetes Mellitus
Yoshida et al.
Toxicol Pathol 1996;24:498-501.
ABSTRACT