This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (49)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of a Case and Review of the Literature

Andrew L. Pecora, MD; Larry Landsman, MD; Stephen P. Imgrund, MD; W. Clark Lambert, MD, PhD

Arch Dermatol. 1983;119(10):820-826.

Abstract
• Acrokeratosis paraneoplastica (Bazex' syndrome) is a rare but clinically distinctive dermatosis that has been associated in all reported cases, to our knowledge, with either a primary malignant neoplasm of the upper aerodigestive tract or metastatic cancer to the lymph nodes of the neck. Acrokeratosis paraneoplastica was found in a 53-year-old black man with squamous cell carcinoma of the tonsil. A distinctive series of changes was found on histopathologic examination of biopsy specimens taken from his skin lesions, and direct immunofluorescence microscopy of both lesional and nonlesional skin specimens showed immunoglobulin and complement deposition on the epidermal basement membrane. The skin lesions largely resolved following radiation therapy of the neoplasm and of the presumably involved lymph nodes.

(Arch Dermatol 1983;119:820-826)

Author Affiliations
From the Department of Internal Medicine, New York Hospital-Memorial Hospital Program (Dr Pecora); and the Departments of Medicine (Drs Landsman and Imgrund) and Pathology/ Dermatopathology (Dr Lambert), the University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark; and the East Orange (NJ) Veterans Administration Medical Center (Drs Landsman and Imgrund).

Footnotes
Accepted for publication Nov 9, 1982.

Reprint requests to the Department of Pathology/Dermatopathology, C520 Medical Science Building, UMDNJ-New Jersey Medical School, 100 Bergen St, Newark, NJ 07103 (Dr Lambert).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acrokeratosis Paraneoplastica (Bazex' Syndrome) Associated With Metastatic Squamous Cell Esophageal Carcinoma
Louvel et al.
JCO 2008;26:5128-5129.
FULL TEXT  

Acral Psoriasiform Eruption in a Man With a Squamous Cell Carcinoma of the Tonsillar Pillar--Diagnosis
Arch Dermatol 2005;141:389-394.
FULL TEXT  

Psoriasiform Dermatitis in a Cachectic Man
Wishner and Lynfield
Arch Dermatol 1988;124:1853-1854.
ABSTRACT