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Morphologic Changes in Epidermis of PUVA-Treated Patients With Psoriasis With or Without a History of Arsenic Therapy
Kirsti-Maria Niemi, MD;
Antti Niemi, Dr Tech;
Lasse Kanerva, MD
Arch Dermatol. 1983;119(11):904-909.
Abstract
• The uninvolved skin of patients with psoriasis was examined microscopically. Atypical nuclear features in keratinocytes and melanocytes were found in about half of the patients. The patients treated with psoralens and UV-A (PUVA) had significantly more of these changes than did patients without PUVA treatment, and the risk was dose dependent. Previous arsenic treatment and x-ray irradiation seemed to have a similar effect. The changes may have been due to the shortwave UV range of the light source.
(Arch Dermatol 1983;119:904-909)
Author Affiliations
From the Department of Dermatology, Helsinki University Central Hospital (Drs K.-M. Niemi and Kanerva) and the Technical Research Center of Finland (Dr A. Niemi), Espoo.
Footnotes
Accepted for publication Oct 9, 1982.
Read in part before the Third Psoriasis Symposium, Stanford, Calif, July 17, 1981.
Reprint requests to Department of Dermatology, University Central Hospital, Snellmaninkatu 14, 00170 Helsinki 17, Finland (Dr K.-M. Niemi).
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