This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinicopathologic Study of 39 Cases

S. A. Buechner, MD; R. K. Winkelmann, MD, PhD

Arch Dermatol. 1983;119(12):979-986.

Abstract
• The histopathologic and clinicopathologic characteristics of 121 skin biopsy specimens from 39 patients with Sézary syndrome were reviewed. The most frequently noted histologic type was a lymphomatoid subepidermal band infiltrate, composed predominantly of atypical lymphoid cells with cerebriform nuclei, found in 53 (44%) of the skin biopsy specimens. A lymphocytic band infiltrate, characterized by a predominance of small lymphocytes and a variable admixture of atypical lymphoid cells, was found in 47 (39%) of the specimens. Only 18 (15%) of the lymphomatoid band specimens from ten patients demonstrated epidermal involvement suggesting mycosis fungoides. Twenty-one (17%) of the biopsy specimens were interpreted as showing changes consistent with those of chronic dermatitis. Despite multiple skin biopsy specimens, there was a weak association noted between the histologic patterns and the clinical stage of disease or the prognosis.

(Arch Dermatol 1983;119:979-986)

Author Affiliations
From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Buechner is a visiting clinician from the University of Basel, Switzerland.

Footnotes
Accepted for publication Oct 26, 1982.

Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Buechner).

CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma
Scarisbrick et al.
Blood 2001;97:624-630.
ABSTRACT | FULL TEXT  

Primary Cutaneous T-Cell Lymphoma: Review and Current Concepts
Siegel et al.
JCO 2000;18:2908-2925.
ABSTRACT | FULL TEXT  

EORTC Classification for Primary Cutaneous Lymphomas: A Proposal From the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer
Willemze et al.
Blood 1997;90:354-371.
ABSTRACT | FULL TEXT  

Sezary-like Syndrome in a 10-Year-Old Girl With Serologic Evidence of Human T-Cell Lymphotropic Virus Type I Infection
Ikai et al.
Arch Dermatol 1987;123:1351-1355.
ABSTRACT