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A Clinicopathologic Study of 39 Cases

S. A. Buechner, MD; R. K. Winkelmann, MD, PhD

Arch Dermatol. 1983;119(12):979-986.

Abstract
• The histopathologic and clinicopathologic characteristics of 121 skin biopsy specimens from 39 patients with Sézary syndrome were reviewed. The most frequently noted histologic type was a lymphomatoid subepidermal band infiltrate, composed predominantly of atypical lymphoid cells with cerebriform nuclei, found in 53 (44%) of the skin biopsy specimens. A lymphocytic band infiltrate, characterized by a predominance of small lymphocytes and a variable admixture of atypical lymphoid cells, was found in 47 (39%) of the specimens. Only 18 (15%) of the lymphomatoid band specimens from ten patients demonstrated epidermal involvement suggesting mycosis fungoides. Twenty-one (17%) of the biopsy specimens were interpreted as showing changes consistent with those of chronic dermatitis. Despite multiple skin biopsy specimens, there was a weak association noted between the histologic patterns and the clinical stage of disease or the prognosis.

(Arch Dermatol 1983;119:979-986)

Author Affiliations
From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Buechner is a visiting clinician from the University of Basel, Switzerland.

Footnotes
Accepted for publication Oct 26, 1982.

Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Buechner).

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