Identification of T-cell Subpopulations in Granuloma Annulare

doi:10.1001/archderm.1983.01650260033012

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Vol. 119 No. 2, February 1983

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Identification of T-cell Subpopulations in Granuloma Annulare

S. A. Buechner, MD; R. K. Winkelmann, MD, PhD; Peter M. Banks, MD

Arch Dermatol. 1983;119(2):125-128.

Abstract

• Granuloma annulare is a lymphohistiocytic process ofunknown cause characterized by necrobiotic dermal papules. Acetone-fixedfrozen sections of eight granuloma annulare lesions were studiedfor the presence of T-cell subsets, using monoclonal antibodiesto T-cell surface antigens. The palisading and perivascularlymphocytic infiltrate shows that most of the mononuclear cellsare reactive with LEU-1 antibody, which characterizes peripheralT cells and activated T cells. Numerous cells were reactivewith LEU-3a antibody, which identifies the helper-inducer T-cellsubset. Some cells were positive with LEU-2a antibody, whichdetects suppressor-cytotoxic cell populations. Masses of histiocyteswere identified infiltrating between the collagen fibers andsurrounding the central necrobiosis area; the histiocytes showeda very strong diffuse acid phosphatase and nonspecific esteraseactivity. These findings suggest that a cell-mediated immuneresponse may be the dominant pathogenic event in granuloma annulare.

(Arch Dermatol 1983;119:125-128)

Author Affiliations

From the Departments of Dermatology (Drs Buechner and Winkelmann) and Surgical Pathology (Dr Banks), Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Buechner is a visiting clinician from the Department of Dermatology, University of Basel (Switzerland).

Footnotes

Accepted for publication April 29, 1982.

Reprint requests to Department of Dermatology, Mayo Clinic,Rochester, MN 55905 (Dr Winkelmann).

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