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Knud Kragballe, MD, PhD; Troels Herlin, MD; Jørgen Ellegaard, MD, PhD

Arch Dermatol. 1983;119(3):203-206.

Abstract
• Antibody-dependent cytotoxicity mediated by purified blood monocytes were determined in untreated patients with plaque-stage mycosis fungoides (MF), parapsoriasis en plaques, exfoliating erythroderma, and noncutaneous malignant lymphoma. Compared with healthy control subjects and control subjects with varicose ulcers, patients with MF had increased monocyte cytotoxicity. In the other dermatoses, normal monocyte cytotoxicity was found. Patients with noncutaneous malignant lymphoma showed normal or decreased monocyte cytotoxicity. There was no evidence that abnormal monocyte cytotoxicity in cutaneous and noncutaneous malignant lymphoma were caused by interaction with lymphocytes or serum. The presence of increased monocyte cytotoxicity in patients with plaque-stage MF may be a clinically useful finding when this diagnosis is suspected clinically but not proved histopathologically.

(Arch Dermatol 1983;119:203-206)

Author Affiliations
From the Department of Dermatology, Marselisborg Hospital (Drs Kragballe and Herlin), and the Department of Medical Hematology, Aarhus (Denmark) Amtssygehus, University of Aarhus (Dr Ellegaard).

Footnotes
Accepted for publication May 25, 1982.

Reprint requests to the Department of Dermatology, Marselisborg Hospital, DK-8000 Aarhus C, Denmark (Dr Herlin).

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