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Uncontrolled Study of Ten Patients

Jean-Claude Roujeau, MD; Chantal Andre, MD; Michèle Joneau Fabre, MD; Philippe Lauret, MD; Marie Laure Flechet, MD; Bernard Kalis, MD; Jean Revuz, MD; René Touraine, MD

Arch Dermatol. 1983;119(3):215-221.

Abstract
• Plasma exchange, together with oral immunosuppressive drugs and various doses of adrenal steroids, were used in the treatment of ten patients with pemphigus. Initially plasma exchange decreased the intercellular antibody (IC Ab) level in all patients and induced a clinical improvement in the conditions of eight of ten patients. This improvement was sustained for the six patients who received simultaneously 0.5 mg/kg/day or more of prednisone. Among the eight patients, four previously corticoresistant patients had perfect control of their disease. Conversely the other four patients, treated with low doses of prednisone. experienced a posttreatment rebound in IC Ab level and showed no or only transient clinical improvement. Plasma exchange may be useful in bringing corticoresistant pemphigus under control but it is not to be used without accompanying high doses of adrenal steroids.

(Arch Dermatol 1983;119:215-221)

Author Affiliations
From the Departments of Dermatology (Drs Roujeau, Revus, and Touraine) and Immunohematology (Dr Andre) and the Creteil Blood Center (Dr Jonneau Fabre), Hôpital Henri Mondor, Creteil, France; the Department of Dermatology, Hôpital Charles Nicolle, Rouen, France (Drs Lauret and Flechet); and the Department of Dermatology, Hôpital Sébastopol, Reims, France (Dr Kalis).

Footnotes
Accepted for publication May 26, 1982.

Reprint requests to Service de Deramatologie, Hôpital Henri Mondor, F 94010 Creteil, France (Dr Roujeau).

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