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Oscar M. Alvarez, PhD; Patricia M. Mertz; William H. Eaglstein, MD

Arch Dermatol. 1983;119(3):222-225.

Abstract
• The effectiveness of 10%, 20%, and 50% benzoyl peroxide in a lotion, 20% benzoyl peroxide in a gel, and the effect of the vehicles alone on wound reepithelialization were evaluated in young domestic pigs. Twenty percent benzoyl peroxide suspension in a lotion base substantially increased the rate of reepithelialization by 33% over a seven-day evaluation period. Twenty percent benzoyl peroxide suspension in a gel base and 10% benzoyl peroxide suspension in a lotion base slightly enhanced epidermal resurfacing, while 50% benzoyl peroxide suspension in a lotion base and the vehicle gel retarded healing. Variations in the rate of reepithelialization were observed when different lots of 20% benzoyl peroxide lotions were compared. Chemical analysis of each of the 20% benzoyl peroxide preparations tested disclosed great differences in zinc, magnesium, and sodium content.

(Arch Dermatol 1983;119:222-225)

Author Affiliations
From the Department of Dermatology, University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication June 26, 1982.

Reprint requests to Department of Dermatology, University of Pittsburgh School of Medicine, RC-513 Scaife Hall, Pittsburgh, PA 15261 (Dr Eaglstein).

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