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Autoantibodies and Their Clinical Significance in a Black Vitiligo Population
Pearl E. Grimes, MD;
Rebat M. Halder, MD;
Connie Jones, MD;
Siba G. Chakrabarti, PhD;
John Enterline, MS;
Harold R. Minus, MD;
John A. Kenney, Jr, MD
Arch Dermatol. 1983;119(4):300-303.
Abstract
• The frequency of autoantibodies was determined in 70 black vitiligo patients and controls. Both groups were screened for antithyroid, antinuclear, antigastric parietal cell, anti-smooth muscle cell, and antimitochondrial autoantibodies. The significance of autoantibodies was determined in vitiligo patients by correlating their presence or absence with various clinical features of the patients. The overall frequencies of autoimmune and endocrine diseases were also assessed in vitiligo patients, controls, and their respective families. Vitiligo patients had an increased frequency of antithyroid antibodies and an increased frequency of autoimmune and/or endocrine diseases. These diseases included, especially, hyperthyroidism, hypothyroidism, and alopecia areata. Autoantibody-positive vitiligo patients had an increased frequency of firstand second-degree relatives having autoimmune and/or endocrine diseases. These findings tend to support an autoimmune cause of vitiligo in black patients.
(Arch Dermatol 1983;119:300-303)
Author Affiliations
From the Department of Dermatology, Vitiligo Center, College of Medicine, Howard University Hospital, Washington, DC.
Footnotes
Accepted for publication July 16, 1982.
Reprint requests to Department of Dermatology, Howard University Hospital, 2041 Georgia Ave NW, Washington, DC 20060 (Dr Grimes).
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ABSTRACT
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