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Cutaneous Lesions in Hairy-Cell LeukemiaCase Report and Review of the Literature
David M. Lawrence, MD;
Nora C. J. Sun, MD;
Raul Mena, MD;
Robert Moss, MD
Arch Dermatol. 1983;119(4):322-325.
Abstract
 A patient is described in whom cutaneous lesions were the initial manifestation of hairy-cell leukemia. Touch preparations made immediately on removal of a 3-mm punch biopsy specimen of the cutaneous lesions revealed acid-phosphatase positive, tartrate-resistant staining in the leukemic cells, and helped to establish the diagnosis. Specific eruptions occur in approximately 7% of patients with hairy-cell leukemia, appearing grossly as disseminated, erythematous maculopapules, with a perivascular mononuclear leukemic cell infiltrate seen microscopically. A review of the English literature indicates that cutaneous manifestations are not generally recognized as a diagnostic source in individuals with hairy-cell leukemia, and biopsy is seldom undertaken.
(Arch Dermatol 1983;119:322-325)
Author Affiliations
From the Departments of Pathology (Drs Lawrence and Sun) and Medicine (Drs Mena and Moss), Harbor-UCLA Medical Center, Torrance, Calif. Dr Lawrence is now in private practice in San Luis Obispo, Calif.
Footnotes
Accepted for publication April 3, 1982.
Reprint requests to Department of Pathology, Box 22, HarborUCLA Medical Center, 1000 W Carlson St, Torrance, CA 90509 (Dr Sun).
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