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Carcinogenic Effect of Sequential Artificial Sunlight and UV-A Irradiation in Hairless MiceConsequences for Solarium `Therapy'
Bent Staberg, MD;
Hans Christian Wulf, MD;
Thomas Poulsen, MD;
Per Klemp, MD;
Holger Brodthagen, MD
Arch Dermatol. 1983;119(8):641-643.
Abstract
• The carcinogenic effect of artificial UV sunlight followed by UV-A irradiation in human solaria doses has been studied with the use of the hairless mouse as an animal model. Artificial sunlight exposure alone induced only a moderate skin tumor incidence (animals with at least one tumor) of 0.15 after one year, and UV-A irradiation alone induced no tumor formation. However, the combination of artificial sunlight exposure and subsequent UV-A irradiation significantly increased the tumor incidence to 0.72. We conclude that, in humans, tanning with UV-A for cosmetic purposes may not be an innocuous procedure.
(Arch Dermatol 1983;119:641-643)
Author Affiliations
From the Departments of Clinical Physiology (Dr Staberg), Dermatology (Drs Wulf, Klemp, and Brodthagen), and Pathology (Dr Poulsen), the Finsen Institute, Copenhagen.
Footnotes
Accepted for publication Dec 22, 1982.
Reprint requests to Department of Clinical Physiology, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark (Dr Staberg).
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