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H. Hunter Handsfield, MD; Sheila A. Lukehart, PhD; Stewart Sell, MD; Steven J. Norris, PhD; King K. Holmes, MD, PhD

Arch Dermatol. 1983;119(8):677-680.

Abstract
• Treponema pallidum was demonstrated in a cutaneous, tertiary syphilitic lesion by indirect immunofluorescence microscopy, but not by darkfield microscopy illumination or silver stain. The numerous organisms observed by this method may help explain the histologically vigorous tissue reaction in tertiary syphilis, despite the scarcity of organisms demonstrable by other methods.

(Arch Dermatol 1983;119:677-680)

Author Affiliations
From the Seattle-King County Department of Public Health (Dr Handsfield); the Departments of Medicine, Harborview Medical Center, Seattle (Dr Handsfield); the Seattle Public Health Hospital (Drs Lukehart and Holmes); the University of Washington School of Medicine (Drs Handsfield, Lukehart, and Holmes); and the Department of Pathology, University of California School of Medicine, San Diego (Drs Sell and Norris).

Footnotes
Accepted for publication Aug 17, 1982.

Reprint requests to Department of Medicine, Harborview Medical Center ZA-85, 325 Ninth Ave, Seattle, WA 98104 (Dr Handsfield).

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