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Hepatitis B Surface Antigen-Containing Immunocomplexes and Polymorphonuclear-Leukocyte Lysosomal Enzyme Release

John E. W. Van de Pette, MRCP; Jacqueline M. Jarvis, FIMLS; J. Mark A. Wilton, MRCPath; Donald M. MacDonald, MA, MB, FRCP

Arch Dermatol. 1984;120(1):109-111.

Abstract
• In a patient with cold-induced cutaneous periarteritis nodosa, cryoprecipitation of a circulating hepatitis B surface antigen-containing immunocomplex resulted in phagocytosis by neutrophils and monocytes with prominent vacuolation of the cells and extracellular release of lysosoma enzymes. We believe this immunocomplex attached itself to the cell membrane and induced vacuolation and degranulation in normal neutrophils.

(Arch Dermatol 1984;120:109-111)

Author Affiliations
From the Departments of Hematology (Dr Van de Pette), Oral Immunology and Microbiology (Ms Jarvis and Dr Wilton), and Dermatology (Dr MacDonald), Guy's Hospital, London.

Footnotes
Accepted for publication Sept 19, 1982.

Reprint requests to the Department of Dermatology, Guy's Hospital, St Thomas' Street, London, SE1 9RT, England (Dr MacDonald).

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