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Morphologic Variations and Developmental Lesions

James L. Finley, MD; Joel M. Noe, MD; Kenneth A. Arndt, MD; Seymour Rosen, MD

Arch Dermatol. 1984;120(11):1453-1455.

Abstract
• Studies have shown that port-wine stains (PWSs) probably represent a progressive ectasia of the superficial cutaneous vascular plexus. During examination of approximately 500 patients with PWSs, seven lesions were identified that could be categorized into two groups. In one group (two patients), the typical superficial PWS was accompanied by a proliferation and ectasia of thin-walled vessels in the deeper dermis, subcutaneous adipose tissue, and skeletal muscle (cavernous hemangioma). In the other group (five patients), single or multiple polypoid tumors arose that consisted of a proliferation of vessels with walls of varying thickness, and intervascular stroma (arteriovenous malformation). These tumors appear to arise in both young patients with flat lesions as well as the older patients with pronounced surface irregularities. Two patients were specifically chosen because they represented the typical PWS cobblestone pattern. This vascular abnormality represents a localized exaggeration of the ectasia process. We conclude that a small number of PWSs are associated with an underlying cavernous hemangioma. Furthermore, besides the surface irregularities that characterize the older PWS, de novo vascular tumors arise that can be categorized as arteriovenous malformations.

(Arch Dermatol 1984;120:1453-1455)

Author Affiliations
From the Departments of Pathology (Drs Finley and Rosen), Surgery (Dr Noe), and Dermatology (Dr Arndt), Beth Israel Hospital and the Harvard Medical School, and the Charles A. Dana Institute, Boston.

Footnotes
Accepted for publication April 24, 1984.

Reprint requests to Department of Pathology, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Rosen).

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