Thalidomide-Induced Peripheral Neuropathy: Effect of Serum Factor on Nerve Cultures

doi:10.1001/archderm.1984.01650470072016

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Vol. 120 No. 11, November 1984

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Thalidomide-Induced Peripheral Neuropathy

Effect of Serum Factor on Nerve Cultures

Iris K. Aronson, MD; Riley Yu, PhD; Dennis P. West, MS; Hans Van Den Broek, MD; Jack Antel, MD

Arch Dermatol. 1984;120(11):1466-1470.

Abstract

• Sensory neuropathies developed in three of four patientswith prurigo nodularis who had been treated with thalidomide.The serum samples of the patients who had neuropathy producedmorphologic changes in cultured dorsal root ganglion cells.These observed changes support the postulate that thalidomideinduces primary neuronal degeneration.

(Arch Dermatol 1984;120:1466-1470)

Author Affiliations

From the Department of Dermatology, College of Medicine (Dr Aronson and Mr West) and the Department of Pharmacy Practice, College of Pharmacy (Mr West), University of Illinois Health Sciences Center, Chicago; the Department of Neurology, University of Chicago, Pritzker School of Medicine (Drs Yu and Antel); and the Department of Dermatology, Hines (Ill) Veterans Administration Medical Center (Dr Van Den Broek).

Footnotes

Accepted for publication Dec 3, 1983.

Reprint requests to Room 376, College of Medicine East Tower,Department of Dermatology, University of Illinois, PO Box 6998,Chicago, IL 60680 (Dr Aronson).

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