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Richard S. Surwit, PhD; Robert S. Gilgor, MD; Lyle M. Allen, MA; Madeleine Duvic, MD

Arch Dermatol. 1984;120(3):329-331.

Abstract
• Nineteen patients with Raynaud's phenomenon in conjunction with progressive systemic sclerosis were given either prazosin hydrochloride (1 mg orally three times a day) or a placebo for eight weeks, after which the treatment procedure was reversed for four weeks. Prazosin was shown to be effective in reducing both the frequency and the severity of vasospasm reported by the patients.

(Arch Dermatol 1984;120:329-331)

Author Affiliations
From the Departments of Psychiatry (Dr Surwit and Mr Allen) and Medicine (Drs Surwit, Gilgor, and Duvic), Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Jan 18, 1983.

Reprint requests to Behavioral Physiology Laboratory, Box 3926, Duke University Medical Center, Durham, NC 27710 (Dr Surwit).

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