This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ole J. Clemmensen, MD; Poul Zander Olsen, MD, PhD; Klaus E. Andersen, MD

Arch Dermatol. 1984;120(3):338-341.

Abstract
• Of six patients treated with thalidomide for either prurigo nodularis or discoid lupus erythematosus, four had paresthesias in the hands and feet and one also complained of muscular pain and stiffness. Clinical neurological findings in all four patients were normal. Subsequent electrophysiological examination disclosed a peripheral neuropathy in five of the six patients; two had electrophysiological signs of a polyneuropathy and three of a carpal tunnel syndrome. Symptoms and abnormal electrophysiological findings were still present in one patient one year after the discontinuation of thalidomide therapy. Since reports on thalidomide neurotoxicity have shown that the neurological symptoms are long standing and possibly irreversible, it is obviously important to inform patients of this possible side effect and to evaluate them closely for the symptoms and electrophysiological signs of evolving neurological changes.

(Arch Dermatol 1984;120:338-341)

Author Affiliations
From the Departments of Dermatology (Drs Clemmensen and Andersen) and Clinical Neurophysiology (Dr Olsen), Gentofte Hospital, Copenhagen.

Footnotes
Accepted for publication Feb 11, 1983.

Reprint requests to Department of Dermatology, Gentofte Hospital, Niels Andersensvej 65, 2900 Hellerup, Denmark (Dr Clemmensen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Development of Neuropathy in Patients With Myeloma Treated With Thalidomide: Patterns of Occurrence and the Role of Electrophysiologic Monitoring
Mileshkin et al.
JCO 2006;24:4507-4514.
ABSTRACT | FULL TEXT  

Thalidomide Treatment for Prurigo Nodularis in Human Immunodeficiency Virus-Infected Subjects: Efficacy and Risk of Neuropathy
Maurer et al.
Arch Dermatol 2004;140:845-849.
ABSTRACT | FULL TEXT  

American Experience With Low-Dose Thalidomide Therapy for Severe Cutaneous Lupus Erythematosus
Duong et al.
Arch Dermatol 1999;135:1079-1087.
ABSTRACT | FULL TEXT  

Thalidomide for Aphthous Ulcers in HIV Infection
Birnkrant et al.
NEJM 1997;337:1086-1087.
FULL TEXT  

Crossover Study of Thalidomide vs Placebo in Jessner's Lymphocytic Infiltration of the Skin
Guillaume et al.
Arch Dermatol 1995;131:1032-1035.
ABSTRACT  

Thalidomide Neuropathy Incidence and Clinicoelectrophysiologic Findings in 42 Patients
Ochonisky et al.
Arch Dermatol 1994;130:66-69.
ABSTRACT  

Crossover Study of Thalidomide vs Placebo in Severe Recurrent Aphthous Stomatitis
Revuz et al.
Arch Dermatol 1990;126:923-927.
ABSTRACT  

Thalidomide Effects in Behcet's Syndrome and Pustular Vasculitis
Jorizzo et al.
Arch Intern Med 1986;146:878-881.
ABSTRACT