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A Multicenter, Double-blind Comparison

Alan R. Shalita, MD; Edgar B. Smith, MD; Eugene Bauer, MD

Arch Dermatol. 1984;120(3):351-355.

Abstract
• The efficacy and safety of topical 1.5% erythromycin solution and 1% clindamycin phosphate solution were compared in the treatment of acne. The number of inflammatory lesions was significantly reduced at 12 weeks by 62% and 59% and the number of noninflammatory lesions by 43% and 39% in the erythromycin and clindamycin groups, respectively. The reduction in lesions was also reflected in the clinical evaluation of the overall facial condition; 73% of the 74 patients treated with erythromycin solution and 62% of the 80 patients treated with clindamycin solution had excellent or good responses at 12 weeks. The results of this study show that topically applied 1.5% erythromycin and 1.0% clindamycin solutions are both effective and comparable in reducing the clinical manifestation of acne in patients with moderate disease.

(Arch Dermatol 1984;120:351-355)

Author Affiliations
From the Department of Dermatology, Downstate Medical Center, Brooklyn, NY (Dr Shalita); the Department of Dermatology, University of Texas Medical Branch, Galveston (Dr Smith); and the Division of Dermatology, Washington University School of Medicine, St Louis (Dr Bauer).

Footnotes
Accepted for publication March 23, 1983.

Reprint requests to Department of Dermatology, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 (Dr Shalita).

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ABSTRACT