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HLA Antigens and Autoantibody Formation in an American Family

Maria Kramarczuk Hordinsky, MD; Helen Hallgren, MS; Douglas Nelson, MD; Alexandra Hult Filipovich, MD

Arch Dermatol. 1984;120(4):464-468.

Abstract
• Ten members of a white American family, spanning three generations, were studied. Three family members from two different generations were affected with hair loss. Two had alopecia universalis; one had alopecia areata. All subjects were HLA-typed using 131 antiserum samples obtained from multiparous female donors defining 41 HLA-A and HLA-B antigen specificities. Six haplotypes were identified. The affected persons and four other family members shared a common haplotype, HLA-A2,B40. The OKT4 (helper), OKT8 (suppressor-cytotoxic) cells, OKT4-OKT8 (helper-suppressor-cytotoxic) ratios and the percentage of B cells found were comparable for both the 12 control subjects and the family members studied. However, family members showed increased autoantibody formation, decreased T-cell percentages, and concanavalin A-induced suppression of the normal lymphocyte response to mitogens.

(Arch Dermatol 1984;120:464-468)

Author Affiliations
From the Departments of Dermatology (Drs Hordinsky and Nelson), Laboratory Medicine and Pathology (Ms Hallgren), and Pediatrics (Division of Immunology) (Dr Filipovich), University of Minnesota Hospitals, Minneapolis. Dr Nelson is now with the University of Virginia, Charlottesville.

Footnotes
Accepted for publication Oct. 6, 1983.

Reprint requests to the Department of Dermatology, PO Box 98, Mayo Memorial Building, University of Minnesota Hospitals, Minneapolis, MN 55455 (Dr Hordinsky).

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