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II. Anaplasias and Unfavorable Outcomes

Tsu-Yi Chuang, MD, MPH; Harold O. Perry, MD; Leonard T. Kurland, MD, DrPH; Duane M. Ilstrup, MS

Arch Dermatol. 1984;120(4):476-483.

Abstract
• A total of 746 patients residing in Rochester, Minn, received the diagnosis of condyloma acuminatum between 1950 and 1978. Anaplasia was present in six and subsequently developed in 36 patients during follow-up examination in 42 patients (one male and 41 female). One had invasive squamous cell carcinoma (vulva), six had severe dysplasias, 21 had moderate to mild dysplasias, and 14 had carcinomas in situ (CIS), of which 11 were cervical. In the female patients, 37 of the anaplasias were cervical and the other four were vulval or vaginal. The 11 cervical CIS amounted to 3.8 times the expected number of 2.9, based on an earlier study of cervical cancer incidence in the community. The risk of cervical CIS developing among patients with condyloma is significantly higher than expected. Neither laryngeal papilloma nor other unfavorable outcomes substantially affected the conceptus of 51 pregnancies in women with concurrent condyloma. There appears to be an association between condyloma and genital malignant neoplasms and a relationship of condyloma with sexually transmitted disease and warts.

(Arch Dermatol 1984;120:476-483)

Author Affiliations
From the Departments of Medical Statistics and Epidemiology (Drs Chuang and Kurland and Mr Ilstrup) and Dermatology (Dr Perry), Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Chuang is now with the Section of Dermatology, University of Chicago.

Footnotes
Accepted for publication June 21, 1983.

Read in part before the 39th annual meeting of the American Academy of Dermatology, New York, Dec 9, 1980, and the eighth annual meeting of the American Society for Dermatologic Surgery, Philadelphia, April 23, 1981.

Reprint requests to Mayo Clinic, Rochester, MN 55905 (Dr Kurland).

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