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Its Association With the Histopathologic and Clinical Criteria of Malignancy

Colin A. Holden, MRCP; Marcia Shaw, MRCP; Philip H. McKee, MB, MRCP; Arnold R. Sanderson, PhD, DSC, FRCP; Donald M. MacDonald, MA, FRCP

Arch Dermatol. 1984;120(6):732-735.

Abstract
• A sensitive immunoperoxidase method employs a new chicken anti-B2-microglobulin (B2M) antibody for use on paraffin sections. The method demonstrates the loss of B2M from the cell membranes of malignant eccrine poromas, and this is correlated with the histopathologic and clinical criteria of malignancy.

(Arch Dermatol 1984;120:732-735)

Author Affiliations
From the Department of Dermatology (Drs Holden and Mac-Donald) and the Medical Research Council Immunology Team (Dr Sanderson), Guy's Hospital, London, and the Departments of Dermatology (Dr Shaw) and Histopathology (Dr McKee), St Thomas' Hospital, London.

Footnotes
Accepted for publication Oct 31, 1983.

Reprint requests to Department of Dermatology, Guy's Hospital, St Thomas Street, London SE1 9RT, England (Dr MacDonald).

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