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Four Cases With Histopathologic, Ultrastructural, and Immunohistologic Observations

David G. Deneau, MD; Gary S. Wood, MD; Jay Beckstead, MD; Richard T. Hoppe, MD; Norman Price, MD

Arch Dermatol. 1984;120(8):1045-1051.

Abstract
• Four patients had localized lesions of Woringer-Kolopp disease (pagetoid reticulosis). The clinical appearances and histopathologic features with light microscopy of the four cases were similar. However, electron microscopy in all four cases and enzyme histochemistry studies and immunophenotyping with monoclonal antibodies in three cases disclosed two subgroups of patients. The features of the predominant cells in the intraepidermal infiltrate of three cases were most consistent with those of helper T lymphocytes with cerebriform nuclei, as found in many cases of mycosis fungoides. In one case, however, the epidermis contained a predominant population of small, medium, and large lymphoid cells of cytotoxic/suppressor T-lymphocyte cell phenotype. It remains to be determined whether Woringer-Kolopp disease is a variant of mycosis fungoides (ie, within the spectrum of the cutaneous T-cell lymphomas), a benign reactive process, or a syndrome with various causes.

(Arch Dermatol 1984;120:1045-1051)

Author Affiliations
From the Departments of Dermatology (Drs Deneau and Price) and Pathology (Dr Wood), and the Division of Radiation Therapy (Dr Hoppe), Stanford (Calif) University Medical Center; and the Department of Pathology, University of California School of Medicine, San Francisco (Dr Beckstead).

Footnotes
Accepted for publication June 3, 1983.

Reprints not available.

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