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Psoralens and UV-A and UV-B Twice Weekly for the Treatment of Psoriasis
Kevin M. Diette, MD;
Khosrow Momtaz-T, MD;
Robert S. Stern, MD;
Kenneth A. Arndt, MD;
John A. Parrish, MD
Arch Dermatol. 1984;120(9):1169-1173.
Abstract
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• In an effort to determine if combination phototherapy (psoralens and UV-A [PUVA]) [PUVA-UV-B]) administered twice weekly provides a substantial advantage over therapy with PUVA alone, we investigated twice-weekly PUVA-UV-B therapy for the treatment of psoriasis. In a bilateral comparison study of 11 patients, we found that seven cases of psoriasis cleared in the same number of treatments with PUVA-UV-B or PUVA, but in four cases the PUVA-UV-B treated side cleared significantly more rapidly. In a study of these 11 split cases, plus ten additional patients treated with PUVA-UV-B twice weekly, this therapy was effective in clearing psoriasis. A bilateral comparison of "aggressive" and "nonaggressive" PUVA and UV-B increments in ten patients suggested that lower doses of PUVA and UV-B may, in the majority of patients, be equally effective. Further study is necessary to define the maximally effective protocol — maximizing clearance yet minimizing UV exposure, acuteside effects, and long-term toxic reactions.
(Arch Dermatol 1984;120:1169-1173)
Author Affiliations
From the Departments of Dermatology, Harvard Medical School, Massachusetts General Hospital (Drs Diette, Momtaz-T, and Parrish), and Beth Israel Hospital (Drs Diette, Stern, and Arndt), Boston.
Footnotes
Accepted for publication Feb 20, 1984.
Reprint requests to Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114 (Dr Parrish).
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